The Catalan giants can make history if they beat Rayo on Thursday night in La Liga after coming from behind to take all three points against Unai Emery's side.
Goals from Lionel Messi and Gerard Pique saw Barcelona come from behind to beat Sevilla 2-1 at the Nou Camp and equal a Spanish record of 34 games without defeat in all competitions.
The visitors took the lead through Vitolo's volley but a superb free kick from Messi levelled the scores on the half-hour mark, and the Argentine then laid on a pass to Luis Suarez who found Pique to put the Catalans in charge early in the second half.
Although Sevilla continued to cause Barca problems, they held on to stay eight points ahead of Atletico Madrid at the top of the Primera Division as well as drawing level with the unbeaten record set by Leo Beenhakker's Real Madrid side in 1989.
The win sees Barca move eight points clear of Atletico Madrid at the top of the table after they beat rivals Real 1-0 on Saturday.
Sevilla were the last side to beat Barcelona in La Liga, recording a 2-1 win over the Catalan giants back in October at the Ramon Sanchez Pizjuan Stadium.
Although Sevilla were also in action in midweek, only returning from Norway on Friday, coach Unai Emery was able to rest players for their Europa League fixture at Molde and named a full-strength side on Sunday with the exception of the suspended Ever Banega.
As with against Arsenal and in many matches this season, Barca made a slow start, constrained by Sevilla's high pressing game. They did create the first real chance of the game though, Vidal slipping the ball to Suarez at the near post, but the Uruguayan was foiled by Sergio Rico.